Publications

Publications
Patents
Thesis
Conferences

Relevant Publications

Year 2023
Year 2022
  • Cañadas-Ortega M, Gómez-Cruz C, Vaquero JJ, Muñoz A. The contribution of microfluidics to fight against tuberculosis. Nanotechnology Reviews.2022. doi: 10.1515/ntrev-2022-0004
  • Brooks C, Vaquero JJ, Muñoz A., Delgado P. Innovations in ex vivo Light Sheet Fluorescence Microscopy. Progress in Biophysics and Molecular Biology. 2022. doi:10.1016/j.pbiomolbio.2021.07.002
  • Muliaditan, M., Teutonico, D., Ortega-Muro, F., Ferrer, S., Della Pasqua, O. Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: Implications for dose
    selection. European Journal of Pharmaceutical Sciences. 2022. doi: 10.1016/j.eps.2022.106163
  • Sibley L,[…] Ferrer-Bazaga S, […], Vaquero JJ, […] Dennis M. Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Thambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection. Pharmaceutics. 2022. doi:10.3390/pharmaceutics1412666
  • P.M. Gordaliza, J.J. Vaquero, A Muñoz-Barrutia. Translational lung imaging analysis through disentangled representations. doi:10.48550/arXiv.2203.01668
Year 2021
  • Voak, A.A., Harris, A., Coteron-Lopez, J.M., Angulo-Barturen, I., Ferrer-Bazaga, S., Croft, S.L., Seifert, K. Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin b and miltefosine in experimental
    visceral leishmaniasis. PLoS Neglected Tropical Diseases, 2021. https://doi.org/10.1371/journal.pntd.0009013
  • Peric, M., Pešić, D., Alihodžić, S., Fajdetić, A., Herreros, E., Gamo, F.J., Angulo-Barturen, I., Jiménez-Díaz, M.B., Ferrer-Bazaga, S., Martínez, M.S., Gargallo-Viola, D., Mathis, A., Kessler, A., Banjanac, M., Padovan, J., Bencetić Mihaljević, V., Munic Kos, V., Bukvić, M., Eraković Haber, V., Spaventi, R. A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides. 2021. doi:10.1111/bph.15292
  • M. C. Ortega; C.C. Gómez; J.J. Vaquero; Muñoz A. (3/4). 2021. The contribution of microfluidics to the fight against tuberculosis Nanotechnology. Reviews. 11/1, pp.40-54. ISSN 2191-9089. https://doi.org/10.1515/ntrev-2022-0004
  • C. Lowe; Ortega, A.; Muñoz A.; J.J. Vaquero. (4/4). 2021. Molecular imaging of pulmonary Tuberculosis in an Ex-Vivo Mouse Model Using Spectral Photon-Counting Computed Tomography and Micro-CT IEEE Access. 9, pp.67201-67208. ISSN 2169-3536. https://doi.org/10.1109/ACCESS.2021.3076432
  • P. Galve; J.M. Udias; A. Lopez M.; F. Arias V., J.J. Vaquero ; D. Menéndez, M.,  Joaquin L. H.. (5/7). 2021. Super-iterative Image Reconstruction in PET IEEE Transactions on Computational Imaging. 7, pp.248-257. ISSN 2333-9403. https://doi.org/10.1109/TCI.2021.3059107
Year 2020
  • A. Lopez M; P. Galve; J. M. Udias, M. ; J. Cal G.; J.J  Vaquero; D. Menéndez, M.; J. L. Herraiz. (5/7). 2020. Real-time 3D PET image with pseudoinverse reconstruction Applied Sciences (MDPI). 10/8, 2829. ISSN 2076-3417. https://doi.org/10.3390/APP10082829
  • Clark, R.D., Morris, D.N., Chinigo, G., Lawless, M.S., Prudhomme, J., Le Roch, K.G., Lafuente, M.J., Ferrer, S., Gamo, F.J., Gadwood, R., Woltosz, W.S. Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones. 2020. doi:10.1007/s10822-020-00333-x
  • Ortega, A.; A. Muñoz; R, J.J.; Guijarro L, L.; J.J. Vaquero. (5/5). 2020. A radiological score for the assessment of tuberculosis progression: Validation in mouse models TUBERCULOSIS. 121. ISSN 1472-9792. https://doi.org/10.1016/j.tube.2020.101918
  • Abella García, M.; Martinez S. C., Desco Menéndez M., J.J.  Vaquero; J. A. Fessler. (4/5). 2020. Simplified statistical image reconstruction for X-ray CT with beam-hardening artifact compensation IEEE TRANSACTIONS ON MEDICAL IMAGING. 39/1, pp.111-118. ISSN 0278-0062. https://doi.org/10.1109/TMI.2019.2921929

  • Kokkonda, S., Deng, X., White, K.L., El Mazouni, F., White, J., Shackleford, D.M., Katneni, K., Chiu, F.C.K., Barker, H., Mclaren, J., Crighton, E., Chen, G., Angulo-Barturen, I., Jimenez-Diaz, M.B., Ferrer, S., Huertas-Valentin, L., Martinez-Martinez, M.S., Lafuente-Monasterio, M.J., Chittimalla, R., Shahi, S.P., Wittlin, S., Waterson, D., Burrows, J.N., Matthews, D., Tomchick, D., Rathod, P.K., Palmer, M.J., Charman, S.A., Phillips, M.A. Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria. 2020. doi:10.1021/acs.jmedchem.0c00311

Year 2019
  • Ortega, A.;J.J. Vaquero ; Gonzalez A., M.; J. Rullas; A. Muñoz. (2/5). 2019. X-ray-based virtual slicing of TB-infected lungs Scientific Reports. 9/1, pp.19404. ISSN 2045-2322. https://doi.org/10.1038/s41598-019-55986-y
  • Perez B. D., CHIL, R.; J.M. Udias M.; Desco Menéndez, M.; J.J. Vaquero. (5/5). 2019. SiPM-based PET detector module for a 4pi span scanner NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. 936, pp.18-21. ISSN 0168-9002. https://doi.org/10.1016/j.nima.2018.10.179
  • Gordaliza, P.M.; A. Muñoz; L.E. Via; S. Sharpe; Desco Menendez, M.; J.J. Vaquero. (6/6). 2019. Computed tomography-based biomarker for longitudinal assessment of disease Burden in pulmonary tuberculosis MOLECULAR IMAGING AND BIOLOGY. 21/1, pp.19-24. ISSN 1536-1632. https://doi.org/10.1007/s11307-018-1215-x
  • Ignacio A. S.; Marcos V. A.;J.J. Vaquero; Desco Menendez, M.;A. Muñoz;[…]. (3/6). 2019. Applications of Light-Sheet Microscopy in Microdevices Frontiers in Neuroanatomy. 13, pp.1-15. ISSN 1662-5129. https://doi.org/10.3389/fnana.2019.00001
  • Thomas, M.G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A.I., Boesche, M., Brand, S., Campbell, L.,Cantizani-Perez, J., Cleghorn, L.A.T., Copley, R.C.B., Crouch, S.D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S.,Gonzalez, S., Gresham, S.L., Hill, A.P., Hindley, S.J., Lowe, R.M., Mackenzie, C.J., Maclean, L., Manthri, S., Martin, F.,Miguel-Siles, J., Nguyen, V.L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos,
    M.T., Reid, I.H., Revill, C., Riley, J., Ruiz-Gomez, J.R., Shishikura, Y., Simeons, F.R.C., Smith, A., Smith, V.C., Spinks, D.,Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D.W., Fiandor, J.M., Gilbert, I.H., Wyatt, P.G., Read, K.D.,Miles, T.J. Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis. 2019. doi: 10.1021/acs.jmedchem.8b01218
Year 2018
  • J. C. González; J.J. Vaquero […](2/8). 2018. Improving PET Quantification of Small Animal [Ga-68]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction
    MOLECULAR IMAGING AND BIOLOGY. 20, pp.584-593. ISSN 1536-1632. https://doi.org/10.1007/s11307-018-1161-7
  • P.M Gordaliza, Muñoz A, Garcia A., D. Menendez,S. Sharpe; J.J. Vaquero. (6/6). 2018. Unsupervised CT lung image segmentation of a mycobacterium tuberculosis infection model Scientific Reports. 8 (9802)/1, pp.1-10. ISSN 2045-2322. https://doi.org/10.1038/s41598-018-28100-x
  • Bueno, J.M., Calderon, F., Chicharro, J., De La Rosa, J.C., Díaz, B., Fernández, J., Fiandor, J.M., Fraile, M.T., García, M., Herreros, E., García-Pérez, A., Lorenzo, M., Mallo, A., Puente, M., Saadeddin, A., Ferrer, S., Angulo-Barturen, I., Burrows, J.N., León, M.L. Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones. doi:10.1021/acs.jmedchem.7b01256
  • G. Konstantinou; D. Pérez-Benito; M. Desco; J. J. Vaquero. A noise correction double time-over-threshold technique for multiplexed read-outs. doi:10.1109/NSSMIC.2018.8824706
  • O’ Neill, P.M., Stocks, P.A., Sabbani, S., Roberts, N.L., Amewu, R.K., Shore, E.R., Aljayyoussi, G., Angulo-Barturén, I., Belén, M., Jiménez-Díaz, Bazaga, S.F., Martínez, M.S., Campo, B., Sharma, R., Charman, S.A., Ryan, E., Chen, G.,
    Shackleford, D.M., Davies, J., Nixon, G.L., Biagini, G.A., Ward, S.A. Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. 2018. doi: 10.1016/j.bmc.2018.05.006
  • Nchinda, A.T., Le Manach, C., Paquet, T., Gonzàlez Cabrera, D., Wicht, K.J., Brunschwig, C., Njoroge, M., Abay, E., Taylor, D., Lawrence, N., Wittlin, S., Jiménez-Díaz, M.-B., Santos Martínez, M., Ferrer, S., Angulo-Barturen, I., Lafuente- Monasterio, M.J., Duffy, J., Burrows, J., Street, L.J., Chibale, K. Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria. 2018. doi:10.1021/acs.jmedchem.8b00382
  • Okour, M., Derimanov, G., Barnett, R., Fernandez, E., Ferrer, S., Gresham, S., Hossain, M., Gamo, F.-J., Koh, G., Pereira, A., Rolfe, K., Wong, D., Young, G., Rami, H., Haselden, J. A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers. 2018. doi: 10.1111/bcp.13476

 

Year 2017
  •  D. Perez-Benio, R. Herrera, R Chill, G Konstantinou, JM Udías, M Desco, JJ Vaquero. Proposal for PET scanner with 4 formula steradian span.  doi:10.1109/NSSMIC.2017.853264
  • G.Konstantinou; R. Chil; M. Desco; J.J Vaquero. Subsurface Laser Engraving Techniques for Scintillator Crystals: Methods, Applications, and Advantages.  doi:10.1109/TRPMS.2017.2714265
  • M. Pompeiano, E. Balaban, J.J. Vaquero, […]. Optimized CUBIC protocol for 3D imaging of chicken embryos at single-cell resolution.
  • Baker, D.A., Stewart, L.B., Large, J.M., Bowyer, P.W., Ansell, K.H., Jiménez-Díaz, M.B., El Bakkouri, M., Birchall, K.,Dechering, K.J., Bouloc, N.S., Coombs, P.J., Whalley, D., Harding, D.J., Smiljanic-Hurley, E., Wheldon, M.C., Walker, E.M., Dessens, J.T., Lafuente, M.J., Sanz, L.M., Gamo, F.-J., Ferrer, S.B., Hui, R., Bousema, T., Angulo-Barturén, I., Merritt, A.T., Croft, S.L., Gutteridge, W.E., Kettleborough, C.A., Osborne, S.A. A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. 2017. doi:10.1038/s41467-017-00572-x
  • Sandoval, E., Lafuente-Monasterio, M.J., Almela, M.J., Castañeda, P., Jiménez Díaz, M.B., Martínez-Martínez, M.S., Vidal, J., Angulo-Barturen, Í., Bamborough, P., Burrows, J., Cammack, N., Chaparro, M.J., Coterón, J.M., De Cozar, C., Crespo, B., Díaz, B., Drewes, G., Fernández, E., Ferrer-Bazaga, S., Fraile, M.T., Gamo, F.J., Ghidelli-Disse, S., Gómez, R., Haselden, J., Huss, S., León, M.L., De Mercado, J., MacDonald, S.J.F., Martín Hernando, J.I., Prats, S., Puente, M., Rodríguez, A., De La Rosa, J.C., Rueda, L., Selenski, C., Willis, P., Wilson, D.M., Witty, M., Calderón, F. The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold. 2017. doi:10.1021/acs.jmedchem.6b01441
  • O’Neill, P.M., Amewu, R.K., Charman, S.A., Sabbani, S., Gnädig, N.F., Straimer, J., Fidock, D.A., Shore, E.R., Roberts, N.L., Wong, M.H.-L., Hong, W.D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo, F.J., Sanz, L., Rodrigues, J., Cortes, C.G., Herreros, E., Angulo-Barturén, I., Jiménez-Díaz, M.B., Bazaga, S.F., Martínez-Martínez, M.S., Campo, B., Sharma, R., Ryan, E., Shackleford, D.M., Campbell, S., Smith, D.A., Wirjanata, G., Noviyanti, R., Price, R.N., Marfurt, J., Palmer, M.J., Copple, I.M., Mercer, A.E., Ruecker, A., Delves, M.J., Sinden, R.E., Siegl, P., Davies, J., Rochford, R., Kocken, C.H.M.,
    Zeeman, A.-M., Nixon, G.L., Biagini, G.A., Ward, S.A. A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. 2017. doi:10.1038/ncomms15159
  • Paquet, T., Le Manach, C., Cabrera, D.G., Younis, Y., Henrich, P.P., Abraham, T.S., Lee, M.C.S., Basak, R., Ghidelli-Disse, S., Lafuente-Monasterio, M.J., Bantscheff, M., Ruecker, A., Blagborough, A.M., Zakutansky, S.E., Zeeman, A.-M., White, K.L., Shackleford, D.M., Mannila, J., Morizzi, J., Scheurer, C., Angulo-Barturen, I., Santosmartínez, M., Ferrer, S., Sanz, L., Gamo, F.J., Reader, J., Botha, M., Dechering, K.J., Sauerwein, R.W., Tungtaeng, A., Vanachayangkul, P., Lim, C.S., Burrows, J., Witty, M.J., Marsh, K.C., Bodenreider, C., Rochford, R., Solapure, S.M., Jiménez-Díaz, M.B., Wittlin, S., Charman, S.A., Donini, C., Campo, B., Birkholtz, L.-M., Khanson, K., Drewes, G., Kocken, C.M., Delves, M.J., Leroy, D., Fidock, D.A., Waterson, D., Street, L.J., Chibale, K. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. 2017. doi: 10.1126/scitranslmed.aad9735
  • Chen, C., Ortega, F., Rullas, J., Alameda, L., Angulo-Barturen, I., Ferrer, S., Simonsson, U.S. The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model. 2017. doi: 10.1007/s10928-017-9508-2

 

Year 2016
  • […], J.J. Vaquero . (5/5). 2016. Functional segmentation of dynamic PET studies: Open source implementation and validation of a leader-follower-based algorithm COMPUTERS IN
  • Phillips, M.A., White, K.L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D.R., Manjalanagara, K., Rudra, K.R., Wirjanata, G., Noviyanti, R., Price, R.N., Marfurt, J., Shackleford, D.M., Chiu, F.C.K., Campbell, M., Jimenez-Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Martinez, M.S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman,A.-M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J.N., Waterson, D., Palmer, M.J., Rathod, P.K., Charman, S.A.. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria doi:10.1021/acsinfecdis.6b00144
  • Le Manach, C., Nchinda, A.T., Paquet, T., Gonzàlez Cabrera, D., Younis, Y., Han, Z., Bashyam, S., Zabiulla, M., Taylor, D.,Lawrence, N., White, K.L., Charman, S.A., Waterson, D., Witty, M.J., Wittlin, S., Botha, M.E., Nondaba, S.H., Reader, J., Birkholtz, L.-M., Jiménez-Díaz, M.B., Martínez, M.S., Ferrer, S., Angulo-Barturen, I., Meister, S., Antonova-Koch, Y.,Winzeler, E.A., Street, L.J., Chibale, K. Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization ofAqueous Solubility and Potency across the Parasite Life Cycle. doi:10.1021/acs.jmedchem.6b01265
  • Chen, C., Ortega, F., Alameda, L., Ferrer, S., Simonsson, U.S.H.
    Population pharmacokinetics, optimised design and sample size determination for rifampicin, isoniazid, ethambutol and pyrazinamide in the mouse.  doi:10.1016/j.ejps.2016.07.017
  • Le Bihan, A., de Kanter, R., Angulo-Barturen, I., Binkert, C., Boss, C., Brun, R., Brunner, R., Buchmann, S., Burrows, J., Dechering, K.J., Delves, M., Ewerling, S., Ferrer, S., Fischli, C., Gamo–Benito, F.J., Gnädig, N.F., Heidmann, B., Jiménez- Díaz, M.B., Leroy, D., Martínez, M.S., Meyer, S., Moehrle, J.J., Ng, C.L., Noviyanti, R., Ruecker, A., Sanz, L.M., Sauerwein, R.W., Scheurer, C., Schleiferboeck, S., Sinden, R., Snyder, C., Straimer, J., Wirjanata, G., Marfurt, J., Price, R.N., Weller, T., Fischli, W., Fidock, D.A., Clozel, M., Wittlin, S. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose– Efficacy Modeling. doi: 10.1371/journal.pmed.1002138
  • Ramón-Garciá, S., González Del Rió, R., Villarejo, A.S., Sweet, G.D., Cunningham, F., Barros, D., Ballell, L., Mendoza- Losana, A., Ferrer-Bazaga, S., Thompson, C.J. Repurposing clinically approved cephalosporins for tuberculosis therapy. doi:10.1038/srep34293
  • Norcross, N.R., Baragaña, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F.R.C., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V.M., Meister, S., Sanz, L., Jiménez-Díaz, B., Angulo-Barturen, I., Ferrer, S., Martínez, M.S., Gamo, F.J., Frearson, J.A., Gray, D.W., Fairlamb, A.H., Winzeler, E.A., Waterson, D., Campbell, S.F., Willis, P., Read, K.D., Gilbert, I.H. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. doi: 10.1021/acs.jmedchem.6b00028
  • Kokkonda, S., Deng, X., White, K.L., Coteron, J.M., Marco, M., De Las Heras, L., White, J., El Mazouni, F., Tomchick, D.R., Manjalanagara, K., Rudra, K.R., Chen, G., Morizzi, J., Ryan, E., Kaminsky, W., Leroy, D., Martínez-Martínez, M.S., Jimenez- Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Waterson, D., Burrows, J.N., Matthews, D., Charman, S.A., Phillips, M.A., Rathod, P.K.
    Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. doi: 10.1021/acs.jmedchem.6b00275
  • Martínez-Hoyos, M., Perez-Herran, E., Gulten, G., Encinas, L., Álvarez-Gómez, D., Alvarez, E., Ferrer-Bazaga, S., García-Pérez, A., Ortega, F., Angulo-Barturen, I., Rullas-Trincado, J., Blanco Ruano, D., Torres, P., Castañeda, P., Huss, S., Fernández Menéndez, R., González del Valle, S., Ballell, L., Barros, D., Modha, S., Dhar, N., Signorino-Gelo, F., McKinney, J.D., García-Bustos, J.F., Lavandera, J.L., Sacchettini, J.C., Jimenez, M.S., Martín-Casabona, N., Castro-Pichel, J.,
    Mendoza-Losana, A. Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor. doi: 10.1016/j.ebiom.2016.05.006
  • McCarthy, J.S., Marquart, L., Sekuloski, S., Trenholme, K., Elliott, S., Griffin, P., Rockett, R., O’Rourke, P., Sloots, T., Angulo-Barturen, I., Ferrer, S., Jiménez-Díaz, M.B., Martínez, M.-S., Hooft Van Huijsduijnen, R., Duparc, S., Leroy, D., Wells,T.N.C., Baker, M., Möhrle, J.J. Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development.doi: 10.1128/AAC.02883-1

Year 2015
  • BIOLOGY AND MEDICINE. 69, pp.181-188. ISSN 0010-4825. https://doi.org/10.1016/j.compbiomed.2015.12.012
  • […], J.J. Vaquero. (4/6). 2015. Tissue-Dependent and Spatially-Variant Positron Range Correction in 3D PET IEEE TRANSACTIONS ON MEDICAL IMAGING. 34/11, pp.2394-2403. ISSN 0278-0062. https://doi.org/10.1109/TMI.2015.2436711
  • […], J.J. Vaquero. (5/7). 2015. Improved quantification for local regions of interest in preclinical PET imaging PHYSICS IN MEDICINE AND BIOLOGY. 60/18, pp.7127-7149. ISSN 0031-9155. https://doi.org/10.1088/0031-9155/60/18/7127
  • […], J.J. Vaquero; P. Kinahan. (1/2). 2015. Positron Emission Tomography: Current Challenges and Opportunities for TechnologicalAdvances in Clinical and Preclinical Imaging Systems Annual Review of Biomedical Engineering. Vol. 17, pp.385-414. ISSN 1523-9829. https://doi.org/10.1146/annurev-bioeng-071114-040723 Annual Review of Biomedical Engineering, pp 385–414, December 2015
  • Ferrer, S., Le Manach, C., Paquet, T., Brunschwig, C., Njoroge, M., Han, Z., Gonzàlez Cabrera, D., Bashyam, S., Dhinakaran, R.,Taylor, D., Reader, J., Botha, M., Churchyard, A., Lauterbach, S., Coetzer, T.L., Birkholtz, L.-M., Meister, S., Winzeler, E.A.,Waterson, D., Witty, M.J., Wittlin, S., Jiménez-Díaz, M.-B., Santos Martínez, M., Ferrer, S., Angulo-Barturen, I., Street, L.J.,Chibale, K. A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. doi:10.1021/acs.jmedchem.5b01605
  • Jiménez-Díaz, M.B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A.M., Myrand-Lapierre, M.-E., O’Loughlin, K.G., Shackleford, D.M., De Almeida, M.J., Carrillo, A.K., Clark, J.A., Dennis, A.S.M., Diep, J., Deng, X., Duffy, S., Endsley, A.N., Fedewa, G., Guiguemde, W.A., Gómez, M.G., Holbrook, G., Horst, J., Kim, C.C., Liu, J., Lee, M.C.S., Matheny, A., SantosMartínez, M., Miller, G., Rodríguez-Alejandre, A., Sanz, L., Sigal, M., Spillman, N.J., Stein, P.D., Wang, Z., Zhu, F., Waterson, D., Knapp, S., Shelat, A., Avery, V.M., Fidock, D.A., Gamo, F.-J., Charman, S.A., Mirsalis, J.C., Ma, H., Ferrer, S., Kirk, K., Angulo-Barturen, I., Kyle, D.E., De Risi, J.L., Floyd, D.M., Guy, R.K. Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1518632112
  • Phillips, M.A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K.L., Njoroge, J.W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D.R., Deng, X., Laird, T., Bhatia, S.N., March, S., Ng, C.L., Fidock, D.A., Wittlin, S., Lafuente-Monasterio, M., Benito, F.J.G., Alonso, L.M.S., Martinez, M.S., Jimenez-Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Haselden, J.N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A.-M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V.M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K.S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M.J., Rathod, P.K., Burrows, J.N., Charman, S.A.  A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. doi:10.1126/scitranslmed.aaa6645
  • Baragaña, B., Hallyburton, I., Lee, M.C.S., Norcross, N.R., Grimaldi, R., Otto, T.D., Proto, W.R., Blagborough, A.M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L.M., Abraham, T.S., Almeida, M.J., Pradhan, A., Porzelle, A., Martínez, M.S., Bolscher, J.M., Woodland, A., Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P.M., Churcher, T.S., Sala, K.A., Zakutansky, S.E., Jiménez-Díaz, M.B., Sanz, L.M., Riley, J., Basak, R., Campbell, M.,Avery, V.M., Sauerwein, R.W., Dechering, K.J., Noviyanti, R., Campo, B., Frearson, J.A., Angulo-Barturen, I., Ferrer-Bazaga, S., Gamo, F.J., Wyatt, P.G., Leroy, D., Siegl, P., Delves, M.J., Kyle, D.E., Wittlin, S., Marfurt, J., Price, R.N., Sinden, R.E., Winzeler, E.A., Charman, S.A., Bebrevska, L., Gray, D.W., Campbell, S., Fairlamb, A.H., Willis, P.A., Rayner, J.C., Fidock,
    D.A., Read, K.D., Gilbert, I.H. A novel multiple-stage antimalarial agent that inhibits protein synthesis. doi:10.1038/nature14451 
  • Gumbo, T., Angulo-Barturen, I., Ferrer-Bazaga, S. Pharmacokinetic-Pharmacodynamic and Dose-Response Relationships of Antituberculosis Drugs: Recommendations and Standards for Industry and Academia. doi:10.1093/infdis/jiu610
  • Malmquist, N.A., Sundriyal, S., Caron, J., Chen, P., Witkowski, B., Menard, D., Suwanarusk, R., Renia, L., Nosten, F., Jiménez-Díaz, M.B., Angulo-Barturen, I., Martínez, M.S., Ferrer, S., Sanz, L.M., Gamo, F.-J., Wittlin, S., Duffy, S., Avery, V.M., Ruecker, A., Delves, M.J., Sinden, R.E., Fuchter, M.J., Scherf, A. Histone methyltransferase inhibitors are orally bioavailable, fast- Acting molecules with activity against different species causing malaria in humans. doi:10.1128/AAC.04419-14
Year 2014
  • Jiménez-Díaz, M.B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A.M., Myrand-Lapierre, M.-E., O’Loughlin, K.G., Shackleford, D.M., De Almeida, M.J., Carrillo, A.K., Clark, J.A., Dennis, A.S.M., Diep, J., Deng, X., Duffy, S., Endsley, A.N., Fedewa, G., Guiguemde, W.A., Gómez, M.G., Holbrook, G., Horst, J., Kim, C.C., Liu, J., Lee, M.C.S., Matheny, A., Martínez, M.S., Miller, G., Rodríguez-Alejandre, A., Sanz, L., Sigal, M., Spillman, N.J., Stein, P.D., Wang, Z., Zhu, F., Waterson, D., Knapp, S., Shelat, A., Avery, V.M., Fidock, D.A., Gamo, F.-J., Charman, S.A., Mirsalis, J.C., Ma, H., Ferrer, S., Kirk, K., Angulo-Barturen, I., Kyle, D.E., Derisi, J.L., Floyd, D.M., Guy, R.K. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. doi:10.1073/pnas.1414221111
  • Ramachandran, S., Hameed P., S., Srivastava, A., Shanbhag, G., Morayya, S., Rautela, N., Awasthy, D., Kavanagh, S., Bharath, S., Reddy, J., Panduga, V., Prabhakar, K.R., Saralaya, R., Nanduri, R., Raichurkar, A., Menasinakai, S., Achar, V., Jiménez-Díaz, M.B., Martínez, M.S., Angulo-Barturen, I., Ferrer, S., Sanz, L.M., Gamo, F.J., Duffy, S., Avery, V.M.,
    Waterson, D., Lee, M.C.S., Coburn-Flynn, O., Fidock, D.A., Iyer, P.S., Narayanan, S., Hosagrahara, V., Sambandamurthy, V.K. N-aryl-2-aminobenzimidazoles: Novel, efficacious, antimalarial lead compounds. doi:10.1021/jm500715u
  • Hameed P, S., Chinnapattu, M., Shanbag, G., Manjrekar, P., Koushik, K., Raichurkar, A., Patil, V., Jatheendranath, S., Rudrapatna, S.S., Barde, S.P., Rautela, N., Awasthy, D., Morayya, S., Narayan, C., Kavanagh, S., Saralaya, R., Bharath, S., Viswanath, P., Mukherjee, K., Bandodkar, B., Srivastava, A., Panduga, V., Reddy, J., Prabhakar, K.R., Sinha, A., Jiménez-Díaz, M.B., Martínez, M.S., Angulo-Barturen, I., Ferrer, S., Sanz, L.M., Gamo, F.J., Duffy, S., Avery, V.M., Magistrado, P.A.,Lukens, A.K., Wirth, D.F., Waterson, D., Balasubramanian, V., Iyer, P.S., Narayanan, S., Hosagrahara, V., Sambandamurthy, V.K., Ramachandran, S. Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents. doi:10.1021/jm500535j
  • Chaparro, M.J., Vidal, J., Angulo-Barturen, I., Bueno, J.M., Burrows, J., Cammack, N., Castañeda, P., Colmenarejo, G., Coteroín, J.M., De Las Heras, L., Fernández, E., Ferrer, S., Gabarroí, R., Gamo, F.J., Garciía, M., Jiménez-Diíaz, M.B., Lafuente, M.J., Leoín, M.L., Martiínez, M.S., Minick, D., Prats, S., Puente, M., Rueda, L., Sandoval, E., Santos-Villarejo, A.,
    Witty, M., Calderoín, F. Case study of small molecules as antimalarials: 2-amino-1-phenylethanol (APE) derivatives. doi:10.1021/ml500015r
  • 36) Lotharius, J., Gamo-Benito, F.J., Angulo-Barturen, I., Clark, J., Connelly, M., Ferrer-Bazaga, S., Parkinson, T., Viswanath, P., Bandodkar, B., Rautela, N., Bharath, S., Duffy, S., Avery, V.M., Möhrle, J.J., Guy, R.K., Wells, T.Repositioning: The fast track to new anti-malarial medicines? doi:10.1186/1475-2875-13-143
  • Vaidya, A.B., Morrisey, J.M., Zhang, Z., Das, S., Daly, T.M., Otto, T.D., Spillman, N.J., Wyvratt, M., Siegl, P., Marfurt, J., Wirjanata, G., Sebayang, B.F., Price, R.N., Chatterjee, A., Nagle, A., Stasiak, M., Charman, S.A., Angulo-Barturen, I., Ferrer, S., Belén Jiménez-Díaz, M., Martínez, M.S., Gamo, F.J., Avery, V.M., Ruecker, A., Delves, M., Kirk, K., Berriman, M., Kortagere, S., Burrows, J., Fan, E., Bergman, L.W.
    Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. doi:10.1038/ncomms6521
Year 2013
    • Bueno, J.M., Manzano, P., García, M.C., Chicharro, J., Puente, M., Lorenzo, M., García, A., Ferrer, S., Gómez, R.M., Fraile, M.T., Lavandera, J.L., Fiandor, J.M., Vidal, J., Herreros, E., Gargallo-Viola, D. Erratum: Potent antimalarial 4-pyridones with improved physico-chemical properties. doi:10.1016/j.bmcl.2013.10.056
    • Angulo-Barturen, I., Ferrer, S. Humanised models of infection in the evaluation of anti-malarial drugs. doi:10.1016/j.ddtec.2012.07.003
    • Jiménez-Díaz, M.B., Viera, S., Ibáñez, J., Mulet, T., Magán-Marchal, N., Garuti, H., Gómez, V., Cortés-Gil, L., Martínez, A., Ferrer, S., Fraile, M.T., Calderón, F., Fernández, E., Shultz, L.D., Leroy, D., Wilson, D.M., García-Bustos, J.F., Gamo, F.J., Angulo-Barturen, I.
      A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery. doi:10.1371/journal.pone.0066967
    • Nilsen, A., LaCrue, A.N., White, K.L., Forquer, I.P., Cross, R.M., Marfurt, J., Mather, M.W., Delves, M.J., Shackleford, D.M., Saenz, F.E., Morrisey, J.M., Steuten, J., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J.X., Sebayang, B.F., Zeeman, A.-M., Noviyanti, R., Sinden, R.E., Kocken, C.H.M., Price, R.N., Avery, V.M., Angulo-Barturen, I., Jiménez-Díaz, M.B., Ferrer, S., Herreros, E., Sanz, L.M., Gamo, F.-J., Bathurst, I., Burrows, J.N., Siegl, P., Guy, R.K., Winter, R.W., Vaidya, A.B., Charman, S.A., Kyle, D.E., Manetsch, R., Riscoe, M.K. Quinolone-3-diarylethers: A new class of antimalarial drug. doi:10.1126/scitranslmed.3005029
Year 2012
    • Bueno, J.M., Herreros, E., Angulo-Barturen, I., Ferrer, S., Fiandor, J.M., Gamo, F.J., Gargallo-Viola, D., Derimanov, G. Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1. doi:10.4155/fmc.12.177
Year 2011
  • Escribano, J., Rivero-Hernández, C., Rivera, H., Barros, D., Castro-Pichel, J., Pérez-Herrán, E., Mendoza-Losana, A., Angulo-Barturen, I., Ferrer-Bazaga, S., Jiménez-Navarro, E., Ballell, L. 4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 invitro Dependent Families of Antitubercular Agents with Moderate invivo Activity. doi:10.1002/cmdc.201100309
  • Sanz, L.M., Jiménez-Díaz, M.B., Crespo, B., De-Cozar, C., Almela, M.J., Angulo-Barturen, I., Castañeda, P., Ibañez, J., Fernández, E.P., Ferrer, S., Herreros, E., Lozano, S., Martínez, M.S., Rueda, L., Burrows, J.N., García-Bustos, J.F., Gamo, F.-J. Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen. doi:10.1128/AAC.05188-11
  • Bueno, J.M., Manzano, P., García, M.C., Chicharro, J., Puente, M., Lorenzo, M., García, A., Ferrer, S., Gómez, R.M., Fraile,
    M.T., Lavandera, J.L., Fiandor, J.M., Vidal, J., Herreros, E., Gargallo-Viola, D. Potent antimalarial 4-pyridones with improved physico-chemical properties. doi: 10.1016/J.BMCL.2011.07.044
  • Coteron, J.M., Marco, M., Esquivias, J., Deng, X., White, K.L., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D.M., Angulo-Barturen, I., Ferrer, S.B., Jiménez-Díaz, M.B., Gamo, F.-J., Goldsmith, E.J., Charman, W.N., Bathurst, I., Floyd, D., Matthews, D., Burrows, J.N., Rathod, P.K., Charman, S.A., Phillips, M.A.
    Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. doi:10.1021/jm200592f
  • Barker Jr., R.H., Urgaonkar, S., Mazitschek, R., Celatka, C., Skerlj, R., Cortese, J.F., Tyndall, E., Liu, H., Cromwell, M., Sidhu, A.B., Guerrero-Bravo, J.E., Crespo-Llado, K.N., Serrano, A.E., Lin, J.-W., Janse, C.J., Khan, S.M., Duraisingh, M., Coleman, B.I., Angulo-Barturen, I., Jiménez-Díaz, M.B., Magán, N., Gomez, V., Ferrer, S., Martínez, M.S., Wittlin, S., Papastogiannidis, P., O’Shea, T., Klinger, J.D., Bree, M., Lee, E., Levine, M., Wiegand, R.C., Munoz, B., Wirth, D.F., Clardy, J., Bathurst, I., Sybertz, E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.  doi:10.1128/AAC.01714-10
Year 2010
  • Coterón, J.M., Catterick, D., Castro, J., Chaparro, M.J., Díaz, B., Fernández, E., Ferrer, S., Gamo, F.J., Gordo, M., Gut, J., De Las Heras, L., Legac, J., Marco, M., Miguel, J., Muñoz, V., Porras, E., De La Rosa, J.C., Ruiz, J.R., Sandoval, E.,Ventosa, P., Rosenthal, P.J., Fiandor, J.M. Erratum: Falcipain inhibitors: Optimization studies of the 2-pyrimidinecarbonitrile lead series. doi:10.1021/jm101228f
  • Coterón, J.M., Catterick, D., Castro, J., Chaparro, M.J., Díaz, B., Fernández, E., Ferrer, S., Gamo, F.J., Gordo, M., Gut, J.,
    De Las Heras, L., Legac, J., Marco, M., Miguel, J., Muñoz, V., Porras, E., De La Rosa, J.C., Ruiz, J.R., Sandoval, E., Ventosa, P., Rosenthal, P.J., Fiandor, J.M. Falcipain inhibitors: Optimization studies of the 2-pyrimidinecarbonitrile lead series. doi:10.1021/jm100556b
  • Guiguemde, W.A., Shelat, A.A., Bouck, D., Duffy, S., Crowther, G.J., Davis, P.H., Smithson, D.C., Connelly, M., Clark, J., Zhu, F., Jiménez-Díaz, M.B., Martinez, M.S., Wilson, E.B., Tripathi, A.K., Gut, J., Sharlow, E.R., Bathurst, I., Mazouni, F.E., Fowble, J.W., Forquer, I., McGinley, P.L., Castro, S., Angulo-Barturen, I., Ferrer, S., Rosenthal, P.J., Derisi, J.L., Sullivan Jr., D.J., Lazo, J.S., Roos, D.S., Riscoe, M.K., Phillips, M.A., Rathod, P.K., Van Voorhis, W.C., Avery, V.M., Guy, R.K. Chemical genetics of Plasmodium falciparum. doi:10.1038/nature09099
1992 - 2008
    • Angulo-Barturen, I., Jiménez-Díaz, M.B., Mulet, T., Rullas, J., Herreros, E., Ferrer, S., Jiménez, E., Mendoza, A., Regadera,
      J., Rosenthal, P.J., Bathurst, I., Pompliano, D.L., de las Heras, F.G., Gargallo-Viola, D. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. doi:10.1371/journal.pone.0002252
    • Xiang, H., McSurdy-Freed, J., Moorthy, G.S., Hugger, E., Bambal, R., Han, C., Ferrer, S., Gargallo, D., Davis, C.B. Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor. doi:10.1002/jps.20681
    • Respaldiza, N., Medrano, F.J., Medrano, A.C., Varela, J.M., de la Horra, C., Montes-Cano, M., Ferrer, S., Wichmann, I., Gargallo-Viola, D., Calderon, E.J. High seroprevalence of Pneumocystis infection in Spanish children. doi:10.1111/j.1469-0691.2004.00974.x
    • Medrano, F.J., Respaldiza, N., Medrano, A., Varela, J.M., Montes-Cano, M., De La Horra, C., Wichmann, I., Ferrer, S., Calderón, E. Seroprevalence of Pneumocystis Human Infection in Southern Spain. doi:10.1111/j.1550-7408.2003.tb00669.x
    • Martinez, A., Ferrer, S., Santos, I., Jimenez, E., Sparrowe, J., Regadera, J., Gomez de las Heras, F., Gargallo-Viola, D. Antifungal activities of two new azasordarins, GW471552 and GW471558, in experimental models of oral and vulvovaginal candidiasis in immunosuppressed rats. doi:10.1128/ACC.45.11.3113-3121.2001
    • Gargallo-Viola, D., Ferrer, S., Tudela, E., Robert, M., Coll, R., Roser, R., Guinea, J. Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-
      azetidin ring substituent. doi:10.1128/AAC.45.11.3113-3121.2001
    • Montes, Ma.J., Belloch, C., Galiana, M., Garcia, Ma.D., Andrés, C., Ferrer, S., Torres-Rodriguez, J.Ma., Guinea, J. Polyphasic taxonomy of a novel yeast isolated from antarctic environment; Description of Cryptococcus victoriae sp. nov. doi:10.1016/S0723-2020(99)80032-0
    • Climent, N., Ferrer, S., Rubires, X., Merino, S., Tomás, J.M., Regué, M.
      Molecular characterization of a 17-kDa outer-membrane protein from Klebsiella pneumonia.doi: 10.1016/S0923-2508(97)87644-9
    • Watanabe, T., Kimura, K., Sumiya, T., Nikaidou, N., Suzuki, K., Suzuki, M., Taiyoji, M., Ferrer, S., Regue, M. Genetic analysis of the chitinase system of Serratia marcescens 2170.doi:10.1128/jb.179.22.7111-7117.1997
    • Enfedaque, J., Ferrer, S., Guasch, J.F., Tomás, J., Regué, M. Bacteriocin 28b from Serratia marcescens N28b: Identification of Escherichia coli surface components involved in bacteriocin binding and translocation. doi:10.1139/m96-004
    • Ferrer, S., Viejo, M.B., Guasch, J.F., Enfedaque, J., Regué, M. Genetic evidence for an activator required for induction of colicin-like bacteriocin 28b production in Serratia marcescens by DNA-damaging agents. doi:10.1128/jb.178.4.951-960.1996
    • Guasch, J.F., Piqué, N., Climent, N., Ferrer, S., Merino, S., Rubires, X., Tomas, J.M., Regué, M. Cloning and characterization of two Serratia marcescens genes involved in core lipopolysaccharide biosynthesis? doi:10.1128/jb.178.19.5741-5747.1996
    • Guasch, J.F., Enfedaque, J., Ferrer, S., Gargallo, D., Regué, M. Bacteriocin 28b, a chromosomally encoded bacteriocin produced by most Serratia marcescens biotypes. doi: 10.1016/0923-2508(96)80293-2
    • Viejo, M.B., Enfedaque, J., Guasch, J.F., Ferrer, S., Regue, M.  Protection against bacteriocin 28b in Serratia marcescens is apparently not related to the expression of an immunity gene. doi:10.1139/m95-030
    • Guasch, J.F., Ferrer, S., Enfedaque, J., Viejo, M.B., Regue, M. A17 kDa outer-membrane protein (Omp4) from Seruatia marcescens confers partial resistance to bacteriocin 28b when expressed in Escherichia coli. doi:10.1099/13500872-141-10-2535
    • Viejo, M.B., Gargallo, D., Ferrer, S., Enfedaque, J., Regue, M. Cloning and DNA sequence analysis of a bacteriocin gene of Serratia marcescens. doi:10.1099/00221287-138-8-1737

    Last decade

    Last decade
    • “Tissue-Dependent and Spatially-Variant Positron Range Correction in 3D PET”, IEEE Transactions On Medical Imaging, vol. 34, no. 11, Nov 2015
    • “Recovery and normalization of triple coincidences in PET”, Medical Physics, vol. 42, no. 3, pp. 1398-1401, doi: 10.1118/1.4908226, 2015
    • “Investigation of different sparsity transforms for the PICCS algorithm in small-animal respiratory gated CT”, PLoS ONE 10 (4): e0120140. doi:10.1371/journal.pone.0120140 2015
    • “MPET Herramienta Innovadora para Imagen PET Multitrazador”, Rev Esp Med Nucl Imagen Mol. 2014;33(Supl 1):119, 2014
    • “In-line high resolution PET and 3T MRI hybrid device for preclinical multimodal imaging”, EJNMMI Physics, 1(Suppl 1):A7 http://www.ejnmmiphys.com/content/1/S1/A7, 2014
    • “Dual-exposure technique for extending the dynamic range of x-ray flat panel detectors”, Phys. Med. Biol., vol. 59, pp. 421–439, 2014
    • “Modification of the TASMIP x-ray spectral model for the simulation of microfocus x-ray sources”, Med. Phys., vol. 41, pp. 011902, http://scitation.aip.org/content/aapm/journal/medphys/41/1/10.1118/1.483…, 2014
    • “MRI compatibility of position-sensitive photomultiplier depth-of-interaction PET detectors modules for in-line multimodality preclinical studies”, Nuc Instr and Methods in Physics Research A, vol. 702, pp. 83-87, 2013
    • “Positron range estimations with PeneloPET”. Phys Med Biol, 58(15): 5127-5152, 2013 A: Sisniega, W. Zbijewski, A. Badal, I.S. Kyprianou, J.W. Stayman, J.J. Vaquero, J.H. Siewerdsen.
    • “Monte Carlo study of the effects of system geometry and antiscatter grids on cone-beam CT scatter distributions”. Med Phys, 40: 051915 (19pp), 2013
    • “Improved dead-time correction for PET scanners: application to small-animal PET”. Phys Med Biol, 58(7): 2059-2072, 2013
    • “Massively parallelizable list-mode reconstruction using a Monte Carlo-based elliptical Gaussian model”. Med Phys, 40(1): 012504 (11pp), 2013
    • “A method for small-animal PET/CT alignment calibration”, Phys. Med. Biol. 57 N199-N207–7518, 2012
    • “Misalignments calibration in small-animal PET scanners based on rotating planar detectors and parallel-beam geometry”, Phys. Med. Biol. 57 7493–7518, 2012
    • “Accuracy of CT-based attenuation correction in PET/CT bone imaging”, Phys. Med. Biol., vol. 57, pp. 2477–2490, 2012
    • “NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems”, J Nuc Med, Vol. 53, no. 8, pp. 1300-1309, 2012
    • “Software architecture for multi-bed FDK-based reconstruction in X-ray CT scanners”, Computer Methods and Programs in Biomedicine, vol. 107, pp. 218-232, 2012
    • “A method for small-animal PET/CT alignment calibration”, Phys Med Biol, Vol. 57, pp. 199–207, 2012
    • “GPU-Based Fast Iterative Reconstruction of Fully 3D PET Sinograms”, IEEE Transactions on Nuclear Science, vol. 58, no. 5, pp. 2257-2263, 2011
    • “Fully 3D GPU PET reconstruction”, Nuclear Instruments and Methods in Physics Research A, vol. 648, pp. S169-S171, 2011
    • “Study of CT-based positron range correction in high resolution 3D PET imaging”, Nuclear Instruments and Methods in Physics Research A, vol. 648, pp. S172-S175, 2011
    • “NEMA NU 4-2008 Performance Measurements of Two Commercial Small-Animal PET Scanners: ClearPET and rPET-1”, IEEE Transactions on Nuclear Science, vol. 58, no. 1, pp. 58-65, 2011

    Patents

    Patents
    • “Procedimiento y dispositivo para la detección y discriminación de eventos válidos en detectores de  radiación gamma”, Country: Spain, Date: 26/10/2009, Patent numbers: 2327594 B2, P200702836
    • “Aparato de adquisición de datos para tomografía computerizada por emisión de radiación gamma y su  funcionamiento”, Country: Spain, Date:05/02/2010, Patent numbers: 2301303, 200502612
    • “Aparato de tomografía multimodalidad”, Country: Spain, Date:15/04/2009, Patent numbers: US8,259,899B2, PCT/ES2006/070150, WO 2007/048867 A1, PCT/ES2006/070160
    • “Multi-Modality  Tomography  Apparatus”,  Country:  United  States  of  America,  Date:27/08/2009,  Patent numbers: WO 2009/127747 A1, PCT/ES2008/000240
    • “Tomography scanner with axially discontinuous detector array”, Country: United States of America, Date: 31/03/2005, Patent numbers: WO 99/24848, PCT/US98/22875
    • “Compact modular, configurable base for position sensitive photomultipliers”,  Country: United States of America, Date: 08/02/2002, Patent numbers: US 6,642,493 B1

    Defended Ph.D. thesis in the last 5 years

    2022

    Archimedean PET: new optimal tessellation.

    David Pérez Benito

    Public defence date: 06/2022.

    Director: Juan José Vaquero

    Current position: Senior researcher in BSEL

    Computer-Aided Assesment of Tuberculosis with Radiological Imaging: From rule-based methods to Deep Learning.UC3M. Supervisor

    Pedro Macías Gordaliza

    Public defence date: 05/2022.

    Director: Juan José Vaquero and A. Muñoz

    Current position: Postdoctoral researcher at the CIBM Center of Biomedical Imaging, Centre Hospitalier Universitaire Vaudois Dèpartement des neurosciences cliniques and EPFL at Lausane (Switzerland)

    Development, characterization, and evaluation of advanced therapies for the treatment of cardiac pathologies.

    Lidia Gomez Cid

    Public defence date: 03/2022.

    Supervisor : Juan José Vaquero and L. Grigorian-Shamagian

    Current position: postdoctoral research fellow at Harvard Medical School and Massachusetts General Hospital (USA)

    2019

    Computational and experimental methods for the assessment of tomographic optical microscopy in the II Near Infrared Window and in Low Scattering Media

    Asier  Marcos Vidal

    Public defence date: 10/2019.

    Director: Juan José Vaquero

    Current position: Optical Microscopy Imaging Specialist at the Whitehead Intitute (USA) after a postdoctoral research fellowship at Harvard Medical School and Massachusetts General Hospital (USA).

    Silicon Photomultipliers for Gamma Radiation Detectors in Nuclear Medicine Applications

    Rigoberto Chil Pérez.

    Public defence date: 09/2019.

    Director: Juan José Vaquero

    Current position: Embedded systems engineer at ViveLibre (Spain).

    Optimization of μCT imaging systems for soft-tissue dedicated tasks

    Ana Ortega-Gil.

    Public defence date: 06/2019.

    Director: Juan José Vaquero

    Current position: Mobile Product Owner at Realeyes-Attention Measurement (UK)

    Thesis in progress

      • Claire Jordan Brooks: Characterization of Tuberculosis in Pre-Clinial Models with Radiotrascriptomics. Supervisors: JJ. Vaquero and A. Mendoza. Expected: 2027 Publications: Progress in Biophysics and Molecular Biology (2022, 2nd author)

      Conferences Contributions

      2024

      2023

      • Ferrer-Bazaga, S. “Animal Models for TB: Several approaches for a key question” 7th Antimicrobial Resistance (AMR) Meeting, Bassel (Suiza), March 2023.
      • Claire Jordan Brooks. Towards and Informational Model for Tuberculosis Lesion Discrimination on X-Ray Images. Red Temática en Biología de Sistemas de Micobacterias Myconet, Universidad Carlos III de Madrid (UC3M), Leganés, Madrid, Spain, September 27, 2023
      • Ferrer-Bazaga, S. “European Regimen Accelerator for Tuberculosis”, Fourteenth International Workshop on Clinical Pharmacology of Tuberculosis Drugs, Virtual Meeting, September 2023.
      • Laura Gutierrez de Pablo, Fernando Bayo, Claire J. Brooks, David Pérez Benito, Patricio López Expósito, Juan José Vaquero. Synchronization in Retrospective Respiratory Gating using Deep Learning. In XLI Congreso Annual de la Sociedad Española de Ingeniería Biomédica (CASEIB), Universidad Politécnica de Cartagena (UPCT), Cartagena, Murcia, Spain, November 22-24, 2023.
      • David Perez Benito, Luis Batres, Rigoberto Chil y Juan José Vaquero. Crystal resolvability evaluation of ASIC for hexagonal SiPM. In XLI Congreso Annual de la Sociedad Española de Ingeniería Biomédica (CASEIB), Universidad Politécnica de Cartagena (UPCT), Cartagena, Murcia, Spain, November 22-24, 2023.
      • Laura Gutierrez de Pablo. Predicción de complicaciones postoperatorias a partir de la actividad neuronal de pacientes pediátricos sometidos a anestecia mediante modelos de Machine Learning. In XLI Congreso Annual de la Sociedad Española de Ingeniería Biomédica (CASEIB), Universidad Politécnica de Cartagena (UPCT), Cartagena, Murcia, Spain, November 22-24, 2023.